![]() 7,8 Further research is therefore warranted to better understand the potential efficacy of renal denervation as a treatment for hypertension. 6,7 Subsequent analyses suggested significant limitations of the study including high failure rate to complete ablation procedural protocol, inexperienced operators, and medication variability. 1 However, the randomized, blinded, sham-controlled SYMPLICTY HTN-3 trial showed a statistically significant reduction from baseline in blood pressure in both the renal denervation and sham control groups, without a significant difference between the two groups. 1,5 Ablation of the renal sympathetic nerves has therefore been proposed as a potential treatment for hypertension.Įarly proof-of-concept and safety studies showed blood pressure-lowering effects with catheter-based renal denervation. ![]() 1 Previous evidence suggest that various neurogenic mechanisms contribute significantly to essential hypertension, 4 most notably increased activity of the renal sympathetic efferent and afferent nerves found within the wall of the renal artery. 3 However, many patients' blood pressure remains uncontrolled despite numerous safe and effective pharmacologic options, which may be due to physician inertia, patient noncompliance with medical therapy, or resistant hypertension. 2 Relative risk reductions for cardiovascular events have been shown to be proportional to the magnitude of blood pressure reduction achieved through treatment. 2 Hypertension is associated with increased risk of coronary heart disease, stroke, heart failure, and peripheral artery disease. 1 In 2010, hypertension was the leading cause of death and disability-adjusted life years worldwide. More than one third of adults in developed countries suffer from hypertension. While the short-term data for renal denervation are quite promising, the long-term efficacy, long-term safety, and impact on cardiovascular event rates are unknown and warrant further research.There were no procedural or device-related major adverse events, suggesting an excellent safety profile. ![]() ![]()
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